The change in the parameters for the climatic elements and phenomena has become the main topic of many current researches. Given to the complexity and the local distinctions of the climatic factors, these changes are not homogenous and thus some regions get warmer, while others get colder, some become more arid, others more humid. The purpose of the current study is to identify the thermo-pluviometric changes recorded in the geographical area localized between the Eastern Carpathians and the Dniester Valley, based on the meteorological data registered between 1961 – 2010 at the Ceahlău-Toaca, Suceava, Iași (in Romania), Chișinău, and Tiraspol (in the Republic of Moldova meteorological stations. In order to determine the evolutionary trends, the Mann-Kendall test was applied combined with Sen`s slope. Therefore, based on the research performed, it was found that, during the 1961 – 2010 period, in the area localized between the Carpathians and the Dniester, there has been a general trend of climatic warming and a slight decrease of the rainfall quantity (especially for the Ceahlău mountain area). This result is confirmed and reinforced by other studies of climate conducted at European level, hence allowing these climate trends to be integrated easily into the general trend of regional warming.