This study delves into assessing drought vulnerability using a comprehensive framework. By leveraging the Drought Vulnerability Index (DVI), the study explores the intricate dynamics within the basin. The exposure component scrutinizes the region's susceptibility to agricultural drought through the SPEI-3 index for the year 2022, coupled with a nuanced analysis of population density across 151 administrative units NUTS-3 from the Danube Basin, Czech Republic and the Republic of Moldova. Sensitivity analysis encompasses critical factors such as the share of crop area from ESRI Land Cover Explorer, the proportion of the aged population (aged 65+), and the prevalence of poverty rates (PPP 2018). Moreover, the evaluation of adaptive capacity incorporates the GDP per capita in $ for each administrative region, shedding light on the region's resilience to mitigate drought impacts. This research offers a holistic perspective on drought vulnerability, emphasizing the need for targeted interventions and adaptive strategies in the study area to enhance resilience and sustainability in the face of changing climatic conditions.