The Emerald Network plays a crucial role in biodiversity conservation, extending the principles of the Natura 2000 framework to non-EU countries and contributing to the long-term protection of natural habitats and biodiversity. The physico-geographical vulnerabilities of the “Vila Nisporeni” Emerald site result from the complex interaction of the region’s geological, geomorphological, climatic, hydrological, pedological and landscape characteristics, each contributing in different ways to the high sensitivity of its natural ecosystems. In addition, presure and threats on natural stands, dominated by oak, which support a unique assemblage of species, including the only wild population of Paeonia peregrina Mill., in the Republic of Moldova, impose establishment of appropriate measures in the Management Plan. In the Management Plan of this site, in addition to the specific measures for the protection of biodiversity, conservation of habitats and emblematic species, improvement of the habitats condition, adequate management, periodic monitoring, according to well-established indicators; measures for education, information and awareness of local communities will also be established (with an emphasis on local natural heritage).