This paper presents an evaluation of the Ipel river basin, examining its sustainable development. It devises methodology for integrated landscape management as a basic tool for the implementation of its sustainable development in actual practice. The main objective of this case study is to define the socio-economic and environmental problems, to design measures to eliminate these problems and/or to prevent new problems arising. The ultimate goal is to achieve management practices which are in harmony with this area’s potential, to the greatest possible extent. Thus, basic principles are applied to landscape-ecological optimization of landscape organisation, including nature protection, biodiversity, landscape stability and the protection of its natural resources. These involve its water and soil and the air/atmosphere in its forests. The protection of its cultural-historical resources is extremely important, including, inter alia, the protection of cultural monuments, protection of historical landscape structures and protection of the entire environment.