A cold microclimate will prompt a reaction to be triggered by heat generation and the effects on the body are decreased sweating, peripheral vascular constriction by increasing the excitability threshold of the Krause corpuscles, cold receptors that maintain the blood pressure control threshold. Hot climatization requires vasodilation and sweating, especially when the air temperature exceeds 29° C. Objectives: To evaluate and present the beneficial effect of the microclimate formed on the upper course of Bârlad from the Central Moldavian Plateau on the human body of the patients with advanced pathology of the locomotor apparatus. Methods: The study was performed on a group of 17 patients aged 63-98 with chronic pathology of the locomotor system, the clinical status being analyzed over a period of 5-10 months sanatorium treatment. The pain scale - Visual Analogic Scale (VAS) was used. Results: The analysis of the clinical status of patients with chronic pathology of the locomotor apparatus for a period of 5-10 months balneary-climatic sanatorial treatment indicated an important improvement due to the climate of the area (VAS Media at the beginning of the evaluation - 7.12, after 5- 10 months of treatment in sanatorium - 3.06, P Stewdent = 0.01). Recommendations: Modeling some limits of microclimatic parameters in order to increase the degree of multifunctional comfort of patients.